SYNTHESIS OF RACEMIC 2-PHOSPHONOMETHYL-1,3-DIOXOLANE NUCLEOSIDE ANALOGS AS POTENTIAL ANTIVIRAL AGENTS

Authors
BEDNARSKI K DIXIT DM MANSOUR TS COLMAN SG WALCOTT SM ASHMAN C
Citation
K. Bednarski et al., SYNTHESIS OF RACEMIC 2-PHOSPHONOMETHYL-1,3-DIOXOLANE NUCLEOSIDE ANALOGS AS POTENTIAL ANTIVIRAL AGENTS, Bioorganic & medicinal chemistry letters, 5(15), 1995, pp. 1741-1744
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
15
Year of publication
1995
Pages
1741 - 1744
Database
ISI
SICI code
0960-894X(1995)5:15<1741:SOR2NA>2.0.ZU;2-X
Abstract
2-Phosphonomethyl-1,3-dioxolane nucleosides containing appropriately l inked pyrimidine and purine bases at C-4 position were prepared as bio mimetic analogues of antiviral 2',3'-dideoxynucleoside monophosphates. The key coupling intermediate 10 was prepared by a cyclocondensation of diethylacetal 6 and diol 7 followed by hydrolysis and lead tetra-ac etate oxidative decarboxylation.