WORTMANNIN AS A UNIQUE PROBE FOR AN INTRACELLULAR SIGNALING PROTEIN, PHOSPHOINOSITIDE 3-KINASE

Authors
UI M OKADA T HAZEKI K HAZEKI O
Citation
M. Ui et al., WORTMANNIN AS A UNIQUE PROBE FOR AN INTRACELLULAR SIGNALING PROTEIN, PHOSPHOINOSITIDE 3-KINASE, Trends in biochemical sciences, 20(8), 1995, pp. 303-307
Citations number
49
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
20
Issue
8
Year of publication
1995
Pages
303 - 307
Database
ISI
SICI code
0968-0004(1995)20:8<303:WAAUPF>2.0.ZU;2-X
Abstract
Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular sign alling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathw ays possible.