TRANSCRIPTIONAL REGULATION OF THE HUMAN T-CELL RECEPTOR DELTA-GENE

T cell receptor delta gene expression is regulated by a T cell-specifi c transcriptional enhancer located within the J(delta)3-C-delta, intro n. An essential element of the enhancer was localized to a small 30 bp segment denoted delta E3. Two specific factors, CBF/PEBP2 and c-Myb, bind to adjacent sites within delta E3 and cooperate functionally to m ediate transcriptional activation. These factors are likely to play es sential roles in the developmental activation of the TCR delta gene in vivo.