C. Stratowa et M. Audette, TRANSCRIPTIONAL REGULATION OF THE HUMAN INTERCELLULAR-ADHESION MOLECULE-1 GENE - A SHORT OVERVIEW, Immunobiology, 193(2-4), 1995, pp. 293-304
Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glyc
oprotein that functions as a ligand for lymphocyte function-associated
antigen-1, plays an important role in mediating cell-cell interaction
s in inflammatory reactions. It is induced by proinflammatory cytokine
s such as interleukin 1, tumor necrosis factor-alpha or interferon-gam
ma, as well as by phorbol esters, retinoic acid and lipopolysaccharide
. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests
that it belongs to the family of acute phase response genes. Investiga
tion of the 5'-regulatory region of the human ICAM-1 gene revealed seq
uence motifs for a variety of transcription factors implicated in tran
scriptional regulation. This review summarizes the current knowledge o
f the transcriptional regulation of the human ICAM-1 gene.