PLASMA ASCORBIC-ACID LEVEL AND ERYTHROCYTE FRAGILITY IN PREECLAMPSIA AND ECLAMPSIA

An imbalance between oxidants and antioxidants in the circulation is b lamed to cause preeclampsia and eclampsia. In this study plasma ascorb ic acid level was analysed in 13 eclamptic, 14 mild preeclamptic, 12 s evere preeclamptic and 20 uncomplicated pregnancies to see whether the re is any correlation with blood pressure, proteinuria, serum triglyce ride level, erythrocyte fragility and leukocyte count. Plasma ascorbic acid level was normal and had no significant difference among the gro ups. Fasting serum triglyceride level was significantly higher in the study group than in the control group but it did not differ among the three study groups. Erythrocyte fragility was found to be increased in all three study groups. Blood leukocyte count was increased in the st udy groups, especially in the eclampsia group. However, plasma ascorbi c acid level and erythrocyte fragility were found to have no significa nt correlation with blood pressure and proteinuria. It was concluded t hat though the ascorbic acid levels were normal in both the study and the control groups, erythrocyte fragility increased probably due to an elevation in peroxide and free radical levels in preeclampsia and ecl ampsia groups, but-without any correlation with the severity of the cl inical picture. Copyright (C) 1997 Elsevier Science Ltd.