CYTOKINE PROFILE IN ACUTE MYELOFIBROSIS ASSOCIATED WITH AGGRESSIVE LARGE GRANULAR LYMPHOCYTE LEUKEMIA

Authors
DALAL BI KEOWN PA PARASKEVAS F WILLIAMS G JOHNSTON JB
Citation
Bi. Dalal et al., CYTOKINE PROFILE IN ACUTE MYELOFIBROSIS ASSOCIATED WITH AGGRESSIVE LARGE GRANULAR LYMPHOCYTE LEUKEMIA, American journal of hematology, 49(4), 1995, pp. 349-352
Citations number
9
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
49
Issue
4
Year of publication
1995
Pages
349 - 352
Database
ISI
SICI code
0361-8609(1995)49:4<349:CPIAMA>2.0.ZU;2-G
Abstract
We report a patient with acute large granular lymphocyte (LGL) leukemi a, presenting as acute myelofibrosis (AMF), The leukemic cells were im mature T-cells (CD5+, CD7+, CD16-, CD56-, CD57-, and CD41-), had monos omy 7, and secreted large amounts of Transforming Growth Factor-beta 1 (TGF-beta 1), The serum levels of interleukins (IL)-2, -2R, -6 and -8 were elevated, while the IL-1 beta, IL-4, and tumor necrosis factor-al pha were normal, (C) 1995 Wiley-Liss, Inc.