INTERACTIONS OF YERSINIA-PESTIS PENICILLIN-BINDING PROTEINS WITH BETA-LACTAM ANTIBIOTICS

Authors
FERREIRA RCC PARK JT CAMELO D DEALMEIDA DF FERREIRA LCS
Citation
Rcc. Ferreira et al., INTERACTIONS OF YERSINIA-PESTIS PENICILLIN-BINDING PROTEINS WITH BETA-LACTAM ANTIBIOTICS, Antimicrobial agents and chemotherapy, 39(8), 1995, pp. 1853-1855
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
8
Year of publication
1995
Pages
1853 - 1855
Database
ISI
SICI code
0066-4804(1995)39:8<1853:IOYPPW>2.0.ZU;2-X
Abstract
The affinities of six major penicillin-binding proteins (PBPs) of Yers inia pestis EV76 to different beta-lactam antibiotics were determined. The results indicate that, similar to their counterparts in Escherich ia coli, PBP2 and PBP3 are the lethal targets of amdinocillin and fura zlocillin, respectively. The PBP contents of four additional Y. pestis strains and the morphological effects produced by some beta-lactam an tibiotics are also reported.