IN-VITRO ACTIVITIES OF PS-15, A NEW DIHYDROFOLATE-REDUCTASE INHIBITOR, AND ITS CYCLIC METABOLITE AGAINST MYCOBACTERIUM-AVIUM COMPLEX

Authors
MEYER SCC MAJUMDER SK CYNAMON MH
Citation
Scc. Meyer et al., IN-VITRO ACTIVITIES OF PS-15, A NEW DIHYDROFOLATE-REDUCTASE INHIBITOR, AND ITS CYCLIC METABOLITE AGAINST MYCOBACTERIUM-AVIUM COMPLEX, Antimicrobial agents and chemotherapy, 39(8), 1995, pp. 1862-1863
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
8
Year of publication
1995
Pages
1862 - 1863
Database
ISI
SICI code
0066-4804(1995)39:8<1862:IAOPAN>2.0.ZU;2-E
Abstract
PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabol ite were evaluated for in vitro activity against 31 clinical Mycobacte rium avium complex isolates. Broth dilution MICs of PS-15 ranged from 16 to 64 mu g/ml. The cyclic metabolite was three to five times more a ctive than the parent compound. Further evaluation of these compounds in an M. avium-infected murine test system will be of interest.