OXA-14, ANOTHER EXTENDED-SPECTRUM VARIANT OF OXA-10 (PSE-2) BETA-LACTAMASE FROM PSEUDOMONAS-AERUGINOSA

Authors
DANEL F HALL LMC GUR D LIVERMORE DM
Citation
F. Danel et al., OXA-14, ANOTHER EXTENDED-SPECTRUM VARIANT OF OXA-10 (PSE-2) BETA-LACTAMASE FROM PSEUDOMONAS-AERUGINOSA, Antimicrobial agents and chemotherapy, 39(8), 1995, pp. 1881-1884
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
8
Year of publication
1995
Pages
1881 - 1884
Database
ISI
SICI code
0066-4804(1995)39:8<1881:OAEVOO>2.0.ZU;2-F
Abstract
Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta- lactams except carbapenems. This beta-lactamase, named OXA-14, corresp onded to OXA-10 (PSE-2) except that aspartate replaced glycine at posi tion 157 and thus is intermediate between OXA-10 and OXA-11, which has aspartate at position 157 and a further substitution at position 143.