TIMING OF PENICILLIN TREATMENT INFLUENCES THE COURSE OF STREPTOCOCCUSPNEUMONIAE-INDUCED MIDDLE-EAR INFLAMMATION

Authors
SATO K QUARTEY MK LIEBELER CL GIEBINK GS
Citation
K. Sato et al., TIMING OF PENICILLIN TREATMENT INFLUENCES THE COURSE OF STREPTOCOCCUSPNEUMONIAE-INDUCED MIDDLE-EAR INFLAMMATION, Antimicrobial agents and chemotherapy, 39(8), 1995, pp. 1896-1898
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
8
Year of publication
1995
Pages
1896 - 1898
Database
ISI
SICI code
0066-4804(1995)39:8<1896:TOPTIT>2.0.ZU;2-K
Abstract
Penicillin treatment timing, using the chinchilla pneumococcal otitis media model, was investigated. Early treatment (when approximately 10( 3) pneumococcal CFU/ml was present in middle ear fluid) significantly accelerated inflammatory-cell influx, whereas late treatment (with app roximately 10(7) pneumococcal CFU/ml present in middle ear fluid) did not. Therefore, antiinflammatory interventions will be needed early in the course of inflammation.