COMPARISON OF DOSE-RESPONSE SLOPES OBTAINED BY SIMULTANEOUS ASSESSMENT OF CHANGES IN FEV(1) AND TRANSCUTANEOUS OXYGEN PARTIAL-PRESSURE DURING METHACHOLINE CHALLENGES IN ASTHMATIC-PATIENTS

Authors
FONTANA GA LAVORINI F BODDI V CAMICIOTTOLI G PANUCCIO P
Citation
Ga. Fontana et al., COMPARISON OF DOSE-RESPONSE SLOPES OBTAINED BY SIMULTANEOUS ASSESSMENT OF CHANGES IN FEV(1) AND TRANSCUTANEOUS OXYGEN PARTIAL-PRESSURE DURING METHACHOLINE CHALLENGES IN ASTHMATIC-PATIENTS, The Journal of asthma, 32(4), 1995, pp. 301-307
Citations number
NO
Categorie Soggetti
Respiratory System",Allergy
Journal title
The Journal of asthma → ACNP
ISSN journal
02770903
Volume
32
Issue
4
Year of publication
1995
Pages
301 - 307
Database
ISI
SICI code
0277-0903(1995)32:4<301:CODSOB>2.0.ZU;2-6
Abstract
We aimed to ascertain whether monitoring changes in transcutaneous (tc ) oxygen partial pressure (PO2) may be used to determine the slope of the dose-response curves to inhaled methacholine. In 10 adult asthmati c patients, FEV(1) and tcPO(2) were simultaneously measured during inh alation of doubling methacholine concentrations. In each patient, the slopes of the methacholine dose-response curves for FEV(1) and tcPO(2) were similar and strongly correlated (r = 0.72; p < 0.05). The result s indicate that tcPO(2) monitoring represents a useful, reliable tool for analysis of the slope of dose-response curves to inhaled methachol ine in asthmatic patients. It can also be used to investigate the path ophysiological implications of bronchial hyperreactivity.