Objective The authors examined the natural history of choledochal cyst
s in adults treated surgically. Background An initial diagnosis of cho
ledochal cyst is uncommon in adults, The recommended treatment is exci
sion, rather than bypass, to achieve effective biliary drainage and be
cause of the risk of cancer. Methods A retrospective study of 27 adult
patients was completed to determine the frequency of anastomotic comp
lications and the incidence of cancer. Results Fifteen patients were t
reated by cyst excision, and one developed an anastomotic stricture, t
reated by percutaneous dilation. Eight of 11 patients treated by cyst
enterostomy required additional surgery for anastomotic revision. A fi
nal patient was treated by T-tube drainage, Five of the seven patients
with cancer have died at a mean of 21.6 months. Conclusion This exper
ience documents the high incidence of cancer (26%), and high rate of s
tricture after cyst enterostomy (73%). The dismal prognosis once cance
r has developed warrants cyst excision, even in asymptomatic patients,
including those with prior cyst enterostomies.