THE SYNTHESIS OF HAPTENS AND PROPERTIES OF CATALYTIC ANTIBODIES DESIGNED TO CATALYZE CARBANIONIC CYCLIZATION REACTIONS

The design of haptens to generate antibodies with the potential to cat alyse carbanionic cyclisation reactions is introduced in the context o f Dieckmann cyclisations and related reactions. Syntheses of five-memb ered ring haptens containing a sulphone, to represent the transition s tate(s) associated with the tetrahedral intermediate, and an amino gro up, to promote the formation of a general base, are described. Results with partially purified antibodies are reported showing that the targ et reaction can be catalysed by antibodies.