USING THE SITE-BINDING MODEL FOR AN EXPLANATION OF THE BLOOD COMPATIBILITY OF SOME MATERIALS USED IN BIOMEDICAL SENSORS

Blood clotting time is the most obvious indication of the biological i ncompatibility of materials that are in contact with blood. The result s of the investigation of blood clotting time are presented for 12 dif ferent materials that are widely used in biomedical chemical-sensor te chnology. The most important factors that define the antithrombogenic properties of materials are the surface-state charges and electrochemi cal phenomena taking place at the solid-state-blood interface. Using t he site-binding model, a mechanism that can explain the high antithrom bogenic properties of some materials is proposed and discussed.