Sh. Ahmed et al., AMPHETAMINE-INDUCED CONDITIONED ACTIVITY IN RATS - COMPARISON WITH NOVELTY-INDUCED ACTIVITY AND ROLE OF THE BASOLATERAL AMYGDALA, Behavioral neuroscience, 109(4), 1995, pp. 723-733
A within-subject design was used to investigate the behavioral and neu
ral basis of the conditioned activity induced by amphetamine in male W
istar rats. In this design, conditioned activity was inferred when the
activity of a given rat following a vehicle injection was greater in
its amphetamine-paired environment (CS+) than in its vehicle-paired en
vironment (CS-). Conditioned activity (a) did not change in magnitude
with the number of conditioning sessions, (b) did not differ from the
level of activity recorded during the first exposure to the CS- (novel
ty), (c) had an extinction rate that was similar to the rate of habitu
tation to the CS-, and (d) was not impaired by a bilateral excitotoxic
lesion of the basolateral amygdala. Results are discussed in light of
the incentive conditioning and habituation theories of conditioned ac
tivity.