GASTRIC EICOSANOID SYNTHESIS IN NORMAL SUBJECTS AND ALCOHOLICS AFTER ETHANOL STIMULATION

This work studied the effect of different ethanol concentrations on th e eicosanoid accumulation in human gastric incubates of healthy volunt eers and chronic alcoholics, determining the in vitro eicosanoid relea se both in the basal condition and after different ethanol concentrati ons, The basal release of PGE(2) and LTC(4) in alcoholics is higher th an in healthy volunteers, Various alcohol concentrations cause an incr ease in LTC(4) and PGE(2) in healthy volunteers; we observed no LTC(4) increase in alcoholics and although PGE(2) levels increased after 20% ethanol, they remained constant at higher ethanol concentrations.