Clinically numerous skin lesions have to be differentiated from malign
ant melanomas. Most important are the benign melanocytic lesions such
as common melanocytic nevi, pigmented spindle cell nevi, Spitz nevi an
d blue nevi. From melanocytic lesions also pigmented non-melanocytic s
kin lesions have to be separated such as seborrhoic keratoses, pigment
ed basal cell carcinomas, verrucae vulgares, dermatofibromas, and vasc
ular lesions such as hemangiomas, pyogenic granuloma, angiokeratoma or
glomus tumors. Diagnostic accuracy in pigmented skin lesions can be d
ramatically improved by dermatoscopy, which is skin surface microscopy
al 10x magnification, using a two step procedure. In the first step m
elanocytic and non-melanocytic lesions are differentiated by the melan
ocytic algorithm. In the second step the malignant potential of the me
lanocytic lesions is evaluated by the ABCD rule of dermatoscopy.