A. Bruni et al., INHIBITION BY CHOLESTERYLPHOSPHORYLSERINE OF T-CELL-MEDIATED IMMUNE-RESPONSES IN MICE, International journal of immunopharmacology, 17(6), 1995, pp. 517-521
The synthetic analogue of phosphatidylserine, cholesterylphosphorylser
ine (CPHS) inhibits T-cell-mediated immune responses in mice. Tested i
n cultured mouse spleen cells, CPHS inhibits concanavalin A-induced ac
tivation of DNA synthesis (IC50, 3.5 mu M). Injected i.p. during the e
fferent phase, CPHS (25-100 mg/kg) inhibits the manifestations of dela
yed-type of hypersensitivity. The compound (25 mg/kg i.p., daily) redu
ces the acute graft-versus-host reaction when given for 5 days to dono
r mice before the isolation of spleen cells used for the inoculum. The
se data suggest that the addition of a phosphorylserine group to a ste
roid ring may produce immunoregulatory compounds.