Fetal axillary cystic hygroma has been reported rarely and only as a s
onographic finding late in gestation. A retrospective study of 19,200
early second trimester screening ultrasonograms for anomalies revealed
five cases of axillary cystic hygroma. All of the axillary hygromas w
ere small, transient, nonloculated cysts. Three cysts were associated
with chromosomal abnormalities: trisomy 21 in two cases and a single c
ase of trisomy 18 in which structural abnormalities also were detected
. Early fetal axillary cystic hygroma appears to be different from pos
tnatal axillary cysts on the basis of differences in prevalence, struc
ture, and appearance. It also may be a normal variant in the developme
nt of the fetal lymphatic system.