MITOGEN-STIMULATED INTERLEUKIN-2 PRODUCTION IN NEVER-MEDICATED, FIRST-EPISODE SCHIZOPHRENIC-PATIENTS - THE INFLUENCE OF AGE AT ONSET AND NEGATIVE SYMPTOMS

Background: Decreased interleukin-2 (IL-2) production is characteristi c of active autoimmune diseases and has previously been reported in pa tients with schizophrenia. We attempted to replicate this finding in n ever-medicated schizophrenic patients and examine the possible correla tion between IL-2 production and clinical variables. Methods: The prod uction of IL-2 was measured in equal numbers (N = 33) of DSM-III-R-dia gnosed schizophrenic patients and controls who were matched for age, r ace, and gender. Patients were also assessed for positive, negative, a nd depressive symptoms. Results: The production of IL-2 was significan tly lower in patients than in controls. There was a significant positi ve correlation between IL-2 production and age at onset, and significa nt negative correlation between IL-2 production and negative symptom s cores. In multivariate analyses, the predictive power was stronger for age at onset than for negative symptoms. Positive or depressive sympt oms were unrelated to IL-2 production. Conclusions: Our finding of low IL-2 production in neuroleptic-naive schizophrenic patients confirms that this finding is not confounded by medications. The correlation of low IL-2 production with younger age at onset suggests that this may be a marker for a subtype of the illness or for severity.