Pyomyositis is a common disease in the tropics, mostly due to Staphylo
coccus aureus. We report two patients infected with the human immunode
ficiency virus (HIV) who presented with fever and unilateral limb swel
ling and in whom pyomyositis was diagnosed in quadriceps and gluteus m
ajor, respectively. Salmonella enter itidis was isolated in both, with
recurrent episodes of muscle involvement and secondary osteomyelitis
in one case. Non-typhi Salmonella pyomyositis may occur in HIV+ patien
ts with a relapsing and aggressive clinical course in some cases.