INTRAARTICULAR PRESSURE CHANGES IN RHEUMATOID AND NORMAL PERIPHERAL JOINTS

Citation
K. Gaffney et al., INTRAARTICULAR PRESSURE CHANGES IN RHEUMATOID AND NORMAL PERIPHERAL JOINTS, Annals of the Rheumatic Diseases, 54(8), 1995, pp. 670-673
Citations number
16
Categorie Soggetti
Rheumatology
ISSN journal
00034967
Volume
54
Issue
8
Year of publication
1995
Pages
670 - 673
Database
ISI
SICI code
0003-4967(1995)54:8<670:IPCIRA>2.0.ZU;2-L
Abstract
Objective-To investigate the intraarticular pressure (IAP) dynamics of a spectrum of joints in rheumatoid and normal subjects in order to de termine whether a reperfusion event is likely to occur at these sites. Methods-IAP was measured in the metacarpophalangeal (MCP) (n = 8), wr ist (n = 8), ankle (n = 4), and elbow joints (n = 4) of rheumatoid sub jects, in addition to the MCP (n = 8), wrist (n = 6), and ankle joints (n = 1) of normal healthy controls, using the hand held portable 295- 1 Intra-Compartmental Pressure Monitor System (Stryker, UK). Results-R esting IAP was positive in all rheumatoid joints, and subatmospheric o r weakly atmospheric in normal subjects (p < 0.01). Exercise produced an increase in IAP in rheumatoid subjects only (p < 0.01). The additio n of saline to normal joints mimicked the IAP changes seen in the rheu matoid group. Conclusion-These observations suggest that increased res ting IAP is a marker for chronic joint inflammation. The LAP increase seen in the rheumatoid group during exercise supports the concept of h ypoxic reperfusion mediated joint injury.