MARKER-VACCINES - NEW CHANCES IN IBR-CONT ROL .1. BOVINE HERPES-VIRUS-1 INFECTIONS AND THE PROBLEM

Infectious Bovine Rhinotracheitis (IBR), caused by Bovine Herpes Virus (BHV1), is a main reason for enormous economic losses in cattle busin ess. Vaccination can prevent clinical symptoms and deaths and furtherm ore reduces the infection risk; however, vaccination was disadvantageo us until today because vaccinated animals could not be differentiated from field-virus infected animals. The fact that some countries of the EC are IBR-free, puts pressure on the other countries to eliminate th e virus. Marker vaccines offer new possibilities to drive effective co ntrol programmes. In this three-part pa per the problem of BHV1-infect ions and nerv chances for control and eradication will he discussed. T he first part summarizes the problems of BHV1-infection in general and various ways to make marker-vaccines are shown. The second part will present results of the development of two recently registered glycopro tein E-deleted vaccines) regarding safety and efficacy. The third par t will elucidate new ways of IBR control by using these marker-vaccine s.