Ga. Nuttall et al., DETERMINATION OF NORMAL VERSUS ABNORMAL ACTIVATED PARTIAL THROMBOPLASTIN TIME AND PROTHROMBIN TIME AFTER CARDIOPULMONARY BYPASS, Journal of cardiothoracic and vascular anesthesia, 9(4), 1995, pp. 355-361
Citations number
35
Categorie Soggetti
Anesthesiology,"Peripheal Vascular Diseas","Cardiac & Cardiovascular System
Objective: The study's objective was to determine the prothrombin time
(PT) and activated partial thromboplastin time (aPTT) values that dif
ferentiated normal from excessively bleeding patients immediately afte
r cardiopulmonary bypass(CPB). Design: A prospective blinded study. Se
tting: A large academic medical center. Participants: 148 patients wer
e studied. Interventions: aPTT and PT were determined by the hospital
laboratory and the Biotrack 512 Coagulation Monitor (Ciba Coming Diagn
ostics, Medfieid, MA) from an arterial whole blood sample obtained 10
minutes after protamine administration. Patients were subjectively and
objectively defined as ''bleeders'' or ''nonbleeders'' with blinded o
bservers. Measurements and Main Results: The specificity and sensitivi
ty were determined by a receiver operating characteristic (ROC) analys
is. Twenty-three of 148 patients (14.9%) were characterized as bleeder
s. The laboratory PT had a maximal specificity and sensitivity of 78%
and 75%, respectively, at a value of 15.4 s, with a negative and posit
ive predictive value of 93% and 33%, respectively. The maximal specifi
city and sensitivity of the laboratory aPTT was 64% and 76%, respectiv
ely, at a value of 46 s, with a negative and positive predictive Value
of 89% and 33%, respectively. aPTT and PT approached normal values af
ter 12 hours in the intensive care unit. Conclusion: The aPTT and PT v
alues that produce the maximal sensitivity and specificity in the ROC
analysis may be helpful to differentiate patients who are bleeding exc
essively from those patients who are not after CPB and to guide transf
usion of blood products. New whole blood coagulation devices with rapi
d turn around times had similar predictive value for bleeding tendency
compared with standardized laboratory tests. Copyright (C) 1995 by W.
B. Saunders Company