We study strong coupling effects in four-dimensional heterotic string
models where supersymmetry is spontaneously broken with large internal
dimensions, consistently with perturbative unification of gauge coupl
ings. These effects give rise to thresholds associated to the dual the
ories: type I superstring or M-theory. In the case of one large dimens
ion, we find that these thresholds appear close to the field-theoretic
al unification scale similar to 10(16) GeV, offering an appealing scen
ario for unification of gravitational and gauge interactions. We also
identify the inverse size of the eleventh dimension of M-theory with t
he energy at which four-fermion effective operators become important.