ONLINE MONITORING OF THE DELIVERY OF THE HEMODIALYSIS PRESCRIPTION

The BioStat 1000 is a new device which employs dialysate-based urea ki netics to calculate the dose of-dialysis (Kt/V) based on a two-pool mo del and protein catabolic rate (PCR). Previous methods relying on bloo d sampling techniques were subject to error and difficult to implement . This paper describes the features of the Biostat and the results of the first clinical validation study with an early prototype. The BioSt at was found to compare favorably with the reference method of direct dialysate quantification (mDDQ) which had been modified to obtain a '' two-pool'' Kt/V. In 31 patients no significant difference was found be tween mean Kt/V from the mDDQ and the mean Kt/V from the BioStat (1.35 +/- 0.33 versus 1.38 +/- 0.36, respectively). The PCR was also not si gnificantly different (53.4 +/- 18.5 g/day versus 51.8 +/- 16 g/day, r espectively). The BioStat was demonstrated to be a convenient method p roducing reliable results.