A CLINICAL-TRIAL OF CYCLOSPORINE-G IN CADAVERIC RENAL-TRANSPLANTATION

Cyclosporine G (OG 37-324) reportedly is an efficacious immunosuppress ant with less nephrotoxicity than cyclosporine A. This is a prospectiv e randomized double-blinded trial comparing cyclosporine G and cyclosp orine A in cadaveric renal transplantation. Patient and graft survival , as well as major infectious complications, were not different betwee n the two groups. Objective parameters of renal function, including se rum creatinine, creatinine clearance, and inulin clearance, were routi nely performed. These generally demonstrated less nephrotoxicity in th ose patients treated with cyclosporine G compared with cyclosporine A. Minor elevations of alanine aminotransferase were noted in the cyclos porine G-treated patients but this was not associated with acute morbi dity. Overall, cyclosporine G appears to be equally as effective as cy closporine A, but demonstrated notably less nephrotoxicity.