Approximately 5% of all patients with gastrointestinal hemorrhage will
not have a bleeding site found after standard evaluation with upper e
ndoscopy and colonoscopy. The source of bleeding in these patients is
often the small intestine. In the past 2 decades, our ability to exami
ne the small bowel endoscopically has been enhanced by the use of intr
aoperative enteroscopy and the development of push and sonde enterosco
pes. In a stepwise evaluation of the patient with obscure gastrointest
inal bleeding using enteroscopy, the identification of a bleeding sour
ce has been reported in 70-100% of patients, usually leading to pallia
tive, if not definitive, therapy. In this review we discuss the indica
tions, methods and yields of each of these procedures, and propose a d
iagnostic algorithm with which to approach these patients.