CAN THE LOSS OF NEGATIVE REGULATION THEORY BE COMPATIBLE WITH THE DEVELOPMENT OF HEMATOLOGICAL MALIGNANCIES - (REVIEW)

The hematological malignancies evolution exhibits significant differen ces with the solid tissue tumor development, especially in the initiat ion step. The loss of negative regulation theory of carcinogenesis was unambiguously demonstrated in the field of colorectal neoplasia, but up to date, several lines of inquiry failed to imply the dysregulation of suppressor genes as an etiologic event in the pathogenesis of leuk emias and lymphomas. Considering the peculiarities of self-renewing he mopoietic cells, we propose in this communication a reconciliation of the loss of negative regulation theory with the blood malignancies dev elopment.