N. Arnaud et al., ACCESS TO MACROCYCLIC LACTAMS - APPLICATION TO A NEW SERIES - THE DIBENZOTETRALACTAMS, Tetrahedron letters, 36(31), 1995, pp. 5531-5534
A facile route is described for the synthesis of macrocyclic dibenzote
tralactams derived from 1,2-diaminobenzene based on a stepwise approac
h using diacid dichlorides or mixed pivalic dianhydrides for ring clos
ure. This method is applicable for the preparation of a variety of rec
eptors of various ring size, heteroatom substitution and pendant chain
s.