Er. Holman et al., QUANTITATIVE-ANALYSIS OF REGIONAL LEFT-VENTRICULAR FUNCTION AFTER MYOCARDIAL-INFARCTION IN THE PIG ASSESSED WITH CINE MAGNETIC-RESONANCE-IMAGING, Magnetic resonance in medicine, 34(2), 1995, pp. 161-169
To assess the accuracy of quantitative analysis of global and regional
wall motion and wall thickening of the left ventricle with cine magne
tic resonance (MR), images obtained in eight pigs before and after myo
cardial infarction were compared with those obtained using gadolinium
diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced multislice spin-
echo MR imaging and determination of pathology. The region with abnorm
al wall motion and wall thickening, as determined with cine MR imaging
, identified the same region of infarction as indicated by Gd-DTPA-enh
anced spin-echo MR imaging and pathology, Within the infarcted region
wall motion and wall thickening analyzed with the centerline method we
re significantly reduced. We conclude that the use of quantitative ana
lysis of cine MR images accurately determines localization and extent
of regional left ventricular dysfunction in the infarcted heart in viv
o. This analysis using dedicated software including the centerline met
hod allows sequential assessment of regional left ventricular function
in normal and infarcted hearts.