In a pacemaker dependent, 60-year-old man with complete heart block, p
rogramming high (5.0 V and 1.0 ms) atrial output and 5.0 volt and 0.5
ms ventricular output while in the DDD mode of a pulse generator, resu
lted in loss of ventricular channel output with resulting asystole, wh
ile the simultaneous, pulse generator produced ECG interpretation chan
nel falsely indicated continuing ventricular channel output. Ventricul
ar pacing was promptly restored by programming to the emergency VVI mo
de. At later operation the atrial lead was determined to be defective,
with a low impedance, while the ventricular lead was intact (lead imp
edance telemetry was not available). The manufacturer has acknowledged
a pulse generator design anomaly that may occur in the setting of a l
ow atrial impedance and issued a Health Safety Alert.