The aim of our experiments was to investigate the possible element con
centration changes in Alzheimer's disease, Our project incorporated th
e determination of the regional distribution of elements in normal hum
an brain, too, Five elements (Al, Zn, Cu, Mn and Fe) have been measure
d in 10 different regions of 20 normal brains (mean age 70 years) and
in brain parts of patients with Alzheimer's disease (9 individuals), A
nalyses were carried out by inductively coupled plasma atomic emission
spectrometry (ICP-AES) and instrumental neutron activation analysis (
INAA) techniques, Analytical precision and accuracy were investigated
by NIST standard reference material, In a comparison between the healt
hy and Alzheimer patients' concentration data using statistical treatm
ent these elements showed difference as a function of the Alzheimer di
sease (AD).