AL, ZN, CU, MN AND FE LEVELS IN BRAIN IN ALZHEIMERS-DISEASE

The aim of our experiments was to investigate the possible element con centration changes in Alzheimer's disease, Our project incorporated th e determination of the regional distribution of elements in normal hum an brain, too, Five elements (Al, Zn, Cu, Mn and Fe) have been measure d in 10 different regions of 20 normal brains (mean age 70 years) and in brain parts of patients with Alzheimer's disease (9 individuals), A nalyses were carried out by inductively coupled plasma atomic emission spectrometry (ICP-AES) and instrumental neutron activation analysis ( INAA) techniques, Analytical precision and accuracy were investigated by NIST standard reference material, In a comparison between the healt hy and Alzheimer patients' concentration data using statistical treatm ent these elements showed difference as a function of the Alzheimer di sease (AD).