SPONTANEOUS APPEARANCE OF HUMAN AND PORCINE FACTOR-VIII INHIBITORS - WHICH THERAPEUTIC APPROACH

An 82-year-old woman presented with severe bleeding due to antibodies inactivating both human and porcine factor VIII. Treatment with porcin e factor VIII was successful in correcting the hemorrhagic manifestati ons, despite the fact that subsequent studies showed that the baseline porcine inhibitor titer was greater than the human inhibitor titer. A namnestic response to porcine factor VIII did not allow us to use it l onger; immunosuppressive therapy, however, was successful in longterm control of the anti-factor VIII antibody titer and in preventing furth er bleeding.