A PERSONAL COMPUTER-BASED SYSTEM FOR PARALLEL LINE ANALYSIS OF BIOASSAY DATA

A program is described for symmetric parallel line analysis of bioassa y data with a logistic dose-response relationship, Dose-response relat ionship is transformed to semilog or log-log. A regression line can be calculated for the dose-response curve for standard and test samples, and produces potency estimate of test sample preparation relative to the standard preparation based on parallel-line bioassay statistical m ethods [3,4], together with detailed analysis of variance, estimates o f slope, intercept and chi(2) test which permits a very sensitive test for linearity and parallelism of standard and test sample and facilit ates detection of 'outliers', i.e, samples exhibiting non-parallelism. The general comparison of dose-response relationships produced by the program are a feature of particular interest.