A NEW METHOD TO EVALUATE THE ELASTIC BEHAVIOR OF TABLETS DURING COMPRESSION

A new method to evaluate elastic/plastic behavior of tablets from tabl et compression force-time data is presented. Tablets were compressed i n an instrumented eccentric single-punch tablet machine. Equations for the calculation of relative elasticity were derived for both upper an d lower punch forces. The experimental work was based on a 3(2) design having binder solution amount and atomizing air pressure as independe nt variables. Multilinear stepwise regression analysis was applied in studying the effects of granulation variables. It was concluded that t he relative elasticity of tablets is dependent on binder solution amou nt. Furthermore, this study showed that the relative elasticity parame ters can be useful in quantification of elastic behavior of tablets.