Mw. Borgdorff et al., HIV-1 INCIDENCE AND HIV-1 ASSOCIATED MORTALITY IN A COHORT OF URBAN FACTORY-WORKERS IN TANZANIA, Genitourinary medicine, 71(4), 1995, pp. 212-215
Objective-To determine HIV-1 incidence and HIV-1 associated mortality
in a prospective cohort study. To determine whether the cohort is suit
able for studies aiming to determine the impact of interventions on HI
V-1 incidence. Methods-The study population was a cohort of 1772 urban
factory workers (1478 men and 294 women) in northwest Tanzania. The s
tudy took place from October 1991 to September 1993. Outcome measures
were HIV-1 seroconversion and death. Results-HIV-1 incidence was 1.2 (
95% Cl 0.7-2.0) per 100 person-years (pyr). Crude annual mortality was
4.9 per 100 pyr in those with and 0.3 in those without HIV-1 infectio
n, giving an age and sex adjusted mortality ratio of 12.9 (95% Cl 5.4-
30.7). Of all deaths, 62% were attributable to HIV-1 infection. Conclu
sion-HIV-1 infection was a major public health problem, being the majo
r cause ofdeath in this adult population. At an HIV-1 incidence of 1.2
per 100 pyr, a large cohort size would be required to evaluate the im
pact of interventions on HIV-1 incidence.