CYCLIC SALIGENYL PHOSPHOTRIESTERS OF 2',3'-DIDEOXY-2',3'-DIDEHYDROTHYMIDINE (D4T) - A NEW PRO-NUCLEOTIDE APPROACH

Authors
MEIER C LOREY M DECLERCQ E BALZARINI J
Citation
C. Meier et al., CYCLIC SALIGENYL PHOSPHOTRIESTERS OF 2',3'-DIDEOXY-2',3'-DIDEHYDROTHYMIDINE (D4T) - A NEW PRO-NUCLEOTIDE APPROACH, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 99-104
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
99 - 104
Database
ISI
SICI code
0960-894X(1997)7:2<99:CSPO2>2.0.ZU;2-A
Abstract
The synthesis of a new pro-nucleotide approach for d4TMP 2 based on cy cloSal-d4TMP 3a-d is described. Phosphotriesters 3 release d4TMP 2 sel ectively by a controlled, chemically induced tandem reaction. CycloSal -phosphotriesters 3 exhibited high biological activity against HIV-1/H IV-2 in CEM cells which was retained in CEM TK- cells. (C) 1997, Publi shed by Elsevier Science Ltd.