SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS .14. 14-ETHOXY-9-METHYL SUBSTITUTED INDOLOMORPHINANS WITH DELTA-OPIOID RECEPTOR SELECTIVITY

Authors
SCHMIDHAMMER H DAURER D WIESER M MONORY K BORSODI A ELLIOTT J TRAYNOR JR
Citation
H. Schmidhammer et al., SYNTHESIS AND BIOLOGICAL EVALUATION OF 14-ALKOXYMORPHINANS .14. 14-ETHOXY-9-METHYL SUBSTITUTED INDOLOMORPHINANS WITH DELTA-OPIOID RECEPTOR SELECTIVITY, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 151-156
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
151 - 156
Database
ISI
SICI code
0960-894X(1997)7:2<151:SABEO1>2.0.ZU;2-P
Abstract
The 5-methyl and 14-ethoxy substituted analogues (compounds 2-4) of th e delta opioid receptor antagonist naltrindole showed similar selectiv ity when compared with the reference drug. Compound 2 was a delta rece ptor antagonist in the mouse vas deferens preparation (MVD) exhibiting considerably higher selectivity ratios than naltrindole, while compou nd 4 was found to be a full and potent delta receptor agonist in the M VD. (C) 1997, Elsevier Science Ltd.