CD27-CD70 INTERACTION - UNRAVELING ITS IMPLICATION IN NORMAL AND NEOPLASTIC B-CELL GROWTH

Members of the Tumour Necrosis Factor-Receptor (TNFR) family play an e ssential role in the control of lymphoid cell growth and differentiati on. The ligand of one of its lymphoid-specific members, CD27, was rece ntly characterized as CD70, a type II transmembrane molecule with homo logy to TNF that is expressed on activated T and B cells. Ligation of CD27 by its natural ligand generates a potent costimulatory signal for cytokine production and proliferation of activated T cells. In contra st to normal B cells, where CD27 expression is confined to germinal ce ntre cells and to a small subset of circulating B lymphocytes, CD27 ex pression is found on a large array of distinct B-cell neoplasia. Here, we review recent data on the expression and function of TNFR family m embers on normal and malignant lymphocytes and propose a role for CD27 -CD70 interaction in B-cell development.