INHIBITION OF MATRIX METALLOPROTEINASES - AN EXAMINATION OF THE S1' POCKET

Authors
MILLER A ASKEW M BECKETT RP BELLAMY CL BONE EA COATES RE DAVIDSON AH DRUMMOND AH HUXLEY P MARTIN FM SAROGLOU L THOMPSON AJ VANDIJK SE WHITTAKER M
Citation
A. Miller et al., INHIBITION OF MATRIX METALLOPROTEINASES - AN EXAMINATION OF THE S1' POCKET, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 193-198
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
193 - 198
Database
ISI
SICI code
0960-894X(1997)7:2<193:IOMM-A>2.0.ZU;2-G
Abstract
Peptidomimetic carboxylate- and hydroxamate-based inhibitors of matrix metalloproteinases containing extended P1' groups have been prepared. Potent inhibition and good selectivity for MMP-2 has been observed fo r the compounds produced. (C) 1997, Elsevier Science Ltd.