THE SYNTHESIS OF (R)-1-(2-OXOCYCLOPENTYLIDEN)-2-ALKANOLS AND THE (S)-FORMS, AND THEIR BIO-ANTIMUTAGENIC ACTIVITY AGAINST UV-INDUCED ESCHERICHIA-COLI WP2 B R TRP/

Authors
IRIYE R TAKAI K NOGUCHI M
Citation
R. Iriye et al., THE SYNTHESIS OF (R)-1-(2-OXOCYCLOPENTYLIDEN)-2-ALKANOLS AND THE (S)-FORMS, AND THEIR BIO-ANTIMUTAGENIC ACTIVITY AGAINST UV-INDUCED ESCHERICHIA-COLI WP2 B R TRP/, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 199-202
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
199 - 202
Database
ISI
SICI code
0960-894X(1997)7:2<199:TSO(AT>2.0.ZU;2-N
Abstract
(R)-1-(2-oxocyclopentyliden)-2-alkanols (1r-a and 1r-b) and the (S)-fo rms, 1s-a and 1s-b, were enantiomerically synthesized from (R)-2-[(R)- O-MEMmandelyloxy]alkanals (6r-a and 6r-b) and the (S)-alkanals, 6s-a a nd 6s-b. The (R)-isomers (1r-a and 1r-b) showed bio-antimutagenic acit ivity against UV-induced Escherichia coli WP2 B/r Trp. (C) 1997, Elsev ier Science Ltd.