DEVELOPMENT OF THE NEW POTENT NONPEPTIDE GPIIB IIIA ANTAGONIST NSL-95301 BY UTILIZING COMBINATORIAL TECHNIQUE/

Authors
HARADA T KATADA J TACHIKI A ASARI T IIJIMA K UNO I OJIMA I HAYASHI Y
Citation
T. Harada et al., DEVELOPMENT OF THE NEW POTENT NONPEPTIDE GPIIB IIIA ANTAGONIST NSL-95301 BY UTILIZING COMBINATORIAL TECHNIQUE/, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 209-212
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
209 - 212
Database
ISI
SICI code
0960-894X(1997)7:2<209:DOTNPN>2.0.ZU;2-3
Abstract
The synthetic study of new non-peptide gpIIb/IIIa antagonist, NSL-9530 1, is presented. The combinatorial technique was engaged in the lead c ompound discovery process and optimization process to find (+)-NSL-953 01. The IC50 value of collagen induced platelet aggregation inhibitory activity is 92 nM. (C) 1997, Elsevier Science Ltd.