A SIMPLIFIED TEMPLATE APPROACH TOWARDS THE SYNTHESIS OF A POTENT BETA-3 ADRENOCEPTOR AGONIST AT THE HUMAN RECEPTOR

Authors
BEELEY LJ BERGE JM CHAPMAN H DEAN DK KELLY J LOWDEN K KOTECHA NR MORGAN HKA RAMI HK THOMPSON M VONG AKK WARD RW
Citation
Lj. Beeley et al., A SIMPLIFIED TEMPLATE APPROACH TOWARDS THE SYNTHESIS OF A POTENT BETA-3 ADRENOCEPTOR AGONIST AT THE HUMAN RECEPTOR, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 219-224
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
219 - 224
Database
ISI
SICI code
0960-894X(1997)7:2<219:ASTATT>2.0.ZU;2-8
Abstract
A simplified template approach was used to delineate the structural re quirements for high potency and intrinsic activity of aryloxypropanola mines as agonists at the human beta-3 adrenoceptor. The information ge nerated was used to prepare selective beta-3 adrenoceptor agonists. (C ) 1997, Elsevier Science Ltd.