ANTIBODY-MEDIATED REGIOSELECTIVE AND ENANTIOSELECTIVE RESOLUTION OF AGLYCEROL DERIVATIVE

Authors
IKEDA K ACHIWA K
Citation
K. Ikeda et K. Achiwa, ANTIBODY-MEDIATED REGIOSELECTIVE AND ENANTIOSELECTIVE RESOLUTION OF AGLYCEROL DERIVATIVE, Bioorganic & medicinal chemistry letters, 7(2), 1997, pp. 225-228
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
2
Year of publication
1997
Pages
225 - 228
Database
ISI
SICI code
0960-894X(1997)7:2<225:ARAERO>2.0.ZU;2-#
Abstract
The antibody-mediated regio- and enantioselective hydrolysis of a glyc erol derivative is reported. (R)-2-Acetoxy-1-(3-nitrobenzyloxy)glycero l (80% ee) was obtained from the (R,S)-2,3-diacetoxy glycerol derivati ve in 36% yield at the antibody-catalyzed kinetic resolution step. (C) 1997, Elsevier Science Ltd.