INTRASELLAR NEURONAL CHORISTOMA ASSOCIATED WITH GROWTH HORMONE-PRODUCING PITUITARY-ADENOMA CONTAINING AMYLOID DEPOSITS

The histological, immunocytochemical, and ultrastructural features of an intrasellar neuronal choristoma associated with pituitary growth ho rmone (GH)producing adenoma are reported. Immunohistochemistry studies and electron microscopy examination showed the adenoma cells to be po sitive for GH but negative for prolactin, and the neurons of the chori stoma to have GH-releasing factor (GRF) neurosecretory activity. The a denoma also had many amyloid deposits in its extracellular space immun oreactive to GRF. This is the first report of the tumor containing amy loid deposits. HUM Copyright (C) 1995 by W.B. Saunders Company.