J. Wojcicki et al., EFFECT OF BUCKWHEAT EXTRACT ON FREE-RADICAL GENERATION IN RABBITS ADMINISTERED HIGH-FAT DIET, PTR. Phytotherapy research, 9(5), 1995, pp. 323-326
In this study the effect of buckwheat extract (BE) on the level of mal
ondialdehyde (MDA), lipids and hormones, and on the concentration of a
scorbate free radicals in the liver (compared with rutin) in animals r
eceiving a high-fat diet (HFD) was measured. Mate mongrel rabbits were
randomly divided into four groups: (1) control, (2) animals given HFD
containing cholesterol and coconut oil, (3) rabbits treated with HFD
+ BE, (4) HFD + rutin, over a period of 12 weeks. The concentration of
MDA in rabbits of group 3 (HFD+BE) was slightly but significantly dec
reased, whilst the number of ascorbate free radicals, examined in vitr
o, in the liver was markedly elevated. The level of testosterone in ra
bbit blood serum (group 3) was increased, but the insulin concentratio
n was significantly diminished (in comparison with group 2). The conte
nt of total cholesterol and triglyceride in the liver of animals maint
ained on BE was decreased. Quite distinct superiority of BE, compared
with rutin, was shown.