UREMIC TOXIN REDUCTION - A NEWLY FOUND EFFECT OF HYDROLYZABLE-TYPE TANNIN-CONTAINING CRUDE DRUG AND GALLOTANNIN

The levels of urea nitrogen, creatinine, methylguanidine and guanidino succinic acid, which accumulate in blood in parallel with the progress of renal failure after adenine administration, were decreased signifi cantly in rats given Galla Rhois, Moutan Cortex or Paeoniae Radix extr act. Administration of Galla Rhois extract was found to be more effect ive than the other two crude drugs in decreasing the uraemic toxin par ameters. A uraemic toxin-decreasing effect similar to that of crude dr ug was also obtained using 1,3,6-tri-O-galloyl-beta-D-glucopyranose an d 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose.