NEUROBLASTOMA-ASSOCIATED OPSOCLONAS-MYOCLONUS TREATED WITH INTRAVENOUSLY ADMINISTERED IMMUNE GLOBULIN-G

An 18-month-old black girl had progressive truncal ataxia, opsoclonus, and multifocal myoclonus associated with a nonresectable abdominal ga nglioneuroblastoma, Before chemotherapy, she received intravenously ad ministered IgG, 1 gm/kg, for 2 days; within 48 hours of the first dose , there was significant improvement of the opsoclonus-myoclonus and at axia, She required a 1 gm/kg maintenance dose every 4 to 6 weeks for a total of 12 doses, but is now free of symptomatic after 2 years with no therapy.