SYNTHETIC STUDY OF CURACIN-A - SYNTHESIS OF PARTIAL STRUCTURE OF CURACIN-A AND ELUCIDATION OF THE ABSOLUTE STEREOCHEMISTRY AT THE METHYLCYCLOPROPYLTHIAZOLINE MOIETY

Authors
ONODA T SHIRAI R KOISO Y IWASAKI S
Citation
T. Onoda et al., SYNTHETIC STUDY OF CURACIN-A - SYNTHESIS OF PARTIAL STRUCTURE OF CURACIN-A AND ELUCIDATION OF THE ABSOLUTE STEREOCHEMISTRY AT THE METHYLCYCLOPROPYLTHIAZOLINE MOIETY, Tetrahedron letters, 36(32), 1995, pp. 5765-5768
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
32
Year of publication
1995
Pages
5765 - 5768
Database
ISI
SICI code
0040-4039(1995)36:32<5765:SSOC-S>2.0.ZU;2-N
Abstract
We defined the absolute configurations of three chiral centers in cura cin A (1), a novel antimitotic agent isolated from a marine cyanobacte rium, as 2R, 19R and 21S, by synthesizing the four stereoisomers of a partial structure of 1, 2-(2-methyl)cyclopropyl-4-(1-propenyl)thiazoli ne, (+)- and (-)- 2a, 2b.